The emerging role of microRNA in regulating the mTOR signaling pathway in immune and inflammatory responses

The mechanistic/mammalian target of rapamycin (mTOR) is considered to be an atypical protein kinase that plays a critical role in integrating different cellular and environmental inputs the form growth factors, nutrients energy and, subsequently, regulating events, including cell metabolism, survival, homeostasis, differentiation. Immunologically, mTOR regulator immune function through numerous signals from microenvironment, which coordinates functions cells T fate decisions. crucial responses has been lately even more appreciated. MicroRNAs (miRNAs) are endogenous, small, noncoding single-stranded RNAs act as molecular regulators involved multiple processes during development, activation effector polarization. Several studies have recently indicated range miRNAs phosphoinositide 3-kinase/protein B/mTOR (PI3K/AKT/mTOR) signaling pathway by targeting components this modulating expression these targets. Current evidence revealed interplay between circuits various types. individual miRNA can affect determine decisions coordinating metabolism. Dysregulation pathway/miRNAs crosstalk reported cancers immune-related diseases. Thus, profiles dysregulated could influence pathway, resulting promotion aberrant immunity. This review summarizes latest information regarding reciprocal orchestrating responses.